Ulf Rosenhall, seniorprofessor

Kort om Ulfs projekt

Arbete: Professor hörselverksamheten
Universitetsanknytning: Göteborgs universitet, Karolinska institutet 
Forskningsprojekt: Treatment of military acoustic accidents with N-Acetyl-L-cysteine (NAC)

"Treatment of military acoustic accidents with N-Acetyl-L-cysteine (NAC)"

Background

N-Acetyl-L-cysteine (NAC) is an antioxidant that protects research animals from noise-induced hearing loss (NIHL) according to numerous studies. Evidence that NAC also is effective in humans is less obvious. 

The Swedish Armed Forces decided in 2011 that NAC should be administered directly after acoustic accidents.

Design

A retrospective, observational study. 

Study sample

Personnel of the Swedish Armed Forces exposed to military acoustic accidents during a five year period. Included in the study were 221 cases (mean age: 22.9 years). Most of the exposures, 84%, were weapon related. NAC (400 mg) was given directly after the accident in 146 cases; 75 had not received NAC.

Results: The prevalence of hearing thresholds ≥25 dB HL, and the incidence of threshold shifts ≥10 dB, was lower in the NAC group than in the Non-NAC group directly after the noise exposure. The deterioration was temporary and not discernable a long time after the accident. The difference was most pronounced in the right ear. The risk reduction to get a temporary hearing loss (TTS), affecting one or both ears was 39% (significant) in the NAC group.

Senast uppdaterad: 2018-12-05 11:24