Biofilm Infection Control (BIC) – Novel approaches to the diagnosis and treatment of chronic periprosthetic and wound infections
MoRE2020 Fellow Margarita Trobos, outgoing mobility from the University of Gothenburg to Navarrabiomed - Biomedical Research Center, Spain
This project addresses two major threats to global health today: chronic biofilm infections and antibiotic resistance, with consequences in patient mortality and healthcare costs. Bacterial biofilms (community of bacterial cells connected by their secreted extracellular matrix) are commonly involved in chronic persistent infections, and are extremely resistant to antibiotics and host defenses. Chronic biofilm infections lead to longer hospital stays, higher medical costs, and increased morbidity and mortality. Orthopaedic implant infections and chronic wounds are examples of chronic biofilm infections and both represent a societal challenge and cause a significant reduced quality of life for patients. The mechanisms surrounding a biofilm infection also play a crucial role in the development of antibiotic resistance – recognized as an international societal problem. The objective of this multidisciplinary project is to increase the scientific knowledge within the field of chronic biofilm infections (associated to medical devices and wound infections) with the main goals of 1) developing diagnostic tools for implant-related infections and; 2) developing novel treatments for chronic wound infections which can act as alternatives for antibiotics. These practical applications will be developed in collaboration with two clinical end-users (Orthopaedics and Infectious Diseases) and one industrial end-user (Mölnlycke Heath Care). Through direct collaboration with end-users this project will impact patient care practices, development of new commercial products and diagnostic methods, therefore being highly relevant for the growth of the region of Västra Götaland in the areas of Life science and Material sciences, strengthening competitiveness and international collaboration.
Collaborating end-users: Mölnlycke Health Care AB, Sahlgrenska University Hospital Department of Orthopedics and Department of Infections diseases