Denna webbplats använder teknik som troligen inte stöds i din webbläsare, därför kan vissa saker se konstiga ut eller inte fungera. Vi rekommenderar att du byter till en modern webbläsare istället.
Gå direkt till huvudinnehållet

Allvarlig coronavirus-smitta i samhället

Minska smittspridningen genom att hålla avstånd till andra och stanna hemma vid minsta förkylningssymptom. Kontakta vården om du känner dig mycket sjuk.

Aktuell information om covid-19 (VGR)

Deciphering machineries underlying disease inclusion body formation for developing early diagnosis markers of neurodegenerative disorders

Beidong Liu. From University of Gothenburg, to Katolieke Universiteit Leuven, Belgium.

Project abstract

The aim of this project is to establish an alliance between the University of Gothenburg (GU) and Katholieke Universiteit Leuven (KU Leuven), Belgium to address machineries underlying neurodegenerative disease which causes a major social challenge on health and wellbeing in Europe highlighted under Horizon 2020.

The research programme focuses on elucidating molecular pathways regulating the formation and clearance of neurodegenerative disease protein inclusions, and to uncover potential bio-markers and targets for early diagnosis of such diseases. Protein misfolding and inclusion body formation are hallmarks of many neurodegenerative and age-related disorders. It reflects failing of protein homeostasis, quality control and clearance systems in the cell. Such system normally prevents the accumulation of toxic protein species as to maintain cell viability. The applicant has expertise in aging, damaged protein segregation, protein quality control and genome-wide high-content screening approaches. These expertises will be further strengthened with the intensive knowledge on biomarker development and humanized yeast neurodegenerative models from KU Leuven partner and their companies. The merging of these complementary expertises in this project will not only advance our understanding of fundamental biological mechanisms of neurodegenerative diseases but also enhance our abilities on developing novel early diagnosis markers with great social and economic potential.

The project will initialize more internationalization activities such as joint Ph.D. training and supervision and mobility of students/researchers for GU. Moreover, it will provide researchers from GU with access to dynamic environments including biotechnology companies and state-of-the-art technologies for research and education. Above all, this partnership will also strengthen and broaden GU partner's abilities on biotechnology business development.

Project summary results

The aim of this project was to establish an alliance between the University of Gothenburg (GU) and Katholieke Universiteit Leuven (KU Leuven), Belgium to address machineries underlying neurodegenerative disease which causes a major social challenge on health and wellbeing in Europe as highlighted under Horizon 2020.

The research Programme focuses on elucidating molecular pathways regulating the formation and clearance of neurodegenerative disease protein inclusions, and to uncover potential bio-markers and targets for early diagnosis of such diseases. Protein misfolding and inclusion body formation are hallmarks of many neurodegenerative and age-related disorders. It reflects failing of protein homeostasis, quality control and clearance Systems in the cell. Such System normally prevents the accumulation of toxic protein species as to maintain cell viability. The applicant has expertise in aging, damaged protein segregation, protein quality control and genome-wide high-content screening approaches. These expertises will be further strengthened with the intensive knowledge on biomarker development and humanized yeast neurodegenerative models from KU Leuven partner and their companies. The merging of these complementary expertises in this project will not only advance our understanding of fundamental biological mechanisms of neurodegenerative diseases but also enhance our abilities on developing novel early diagnosis markers with great social and economic potential. The project has totally produced 5 research papers/reviews in the proposed field.

The project has initialized internationalization activities such as joint Ph.D. training, supervision and mobility of researchers for GU. Moreover, the collaboration established will provide researchers from GU with access to dynamic environments including biotechnology companies and state-of-the-art technologies for research and education. Above all, the established partnership will also strengthen and broaden GU partner's abilities on biotechnology business development.

 

Senast uppdaterad: 2018-04-11 12:28